Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 59, Issue 11, Pages 7113-7116Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01394-15
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Funding
- Guangxi Natural Science Foundation Programs [2012GXNSFBA053052, 2013GXNSFAA019070]
- National Natural Science Foundation of China [31201862]
- German Federal Ministry of Education and Research (BMBF) through the German Aerospace Center (DLR) [01KI1301D]
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A novel nonconjugative plasmid of 28,489 bp from a porcine linezolid-resistant Enterococcus faecium isolate was completely sequenced. This plasmid harbored a novel type of multiresistance gene cluster that comprised the resistance genes lnu(B), lsa(E), spw, aadE, aphA3, and two copies of erm(B), which account for resistance to macrolides, lincosamides, streptogramins, pleuromutilins, streptomycin, spectinomycin, and kanamycin/neomycin. Structural comparisons suggested that this plasmid might have developed from other enterococcal plasmids by insertion element (IS)-mediated interplasmid recombination processes.
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