Journal
NATURE CELL BIOLOGY
Volume 17, Issue 3, Pages 241-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3106
Keywords
-
Categories
Funding
- MINECO [BFU2011-22622]
- CONSOLIDER [CSD2009-00016]
- NIH [SAF2013-44857-R, 1DP2OD006486, AGL2013-48998-C2-2]
- CSIC JAE PhD fellowship
- Fundacion Obra Social 'La Caixa' PhD fellowship
- Amarouto Program tor senior researchers from the Comunidad Autonoma de Madrid
- Bill and Melinda Gates Foundation [OPP1108132] Funding Source: Bill and Melinda Gates Foundation
- Bill & Melinda Gates Foundation - Grand Challenges Explorations Initiative [OPP1108132] Funding Source: researchfish
Ask authors/readers for more resources
Epithelial organs develop through tightly coordinated events of cell proliferation and differentiation in which endocytosis plays a major role. Despite recent advances, how endocytosis regulates the development of vertebrate organs is still unknown. Here we describe a mechanism that facilitates the apical availability of endosomal SNARE receptors for epithelial morphogenesis through the developmental upregulation of plasmolipin (pllp) in a highly endocytic segment of the zebrafish posterior midgut. The protein PLLP (Pllp in fish) recruits the clathrin adaptor EpsinR to sort the SNARE machinery of the endolysosomal pathway into the subapical compartment, which is a switch for polarized endocytosis. Furthermore, PLLP expression induces apical Crumbs internalization and the activation of the Notch signalling pathway, both crucial steps in the acquisition of cell polarity and differentiation of epithelial cells. We thus postulate that differential apical endosomal SNARE sorting is a mechanism that regulates epithelial patterning.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available