Journal
NATURE CELL BIOLOGY
Volume 17, Issue 4, Pages 351-359Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3124
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Funding
- N.I.H. [CA157996]
- Cancer Prevention and Research Institute of Texas [RP130272]
- V Foundation
- N.I.H. Training Grant [5T32CA124334-08]
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Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.
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