Journal
NATURE CELL BIOLOGY
Volume 17, Issue 5, Pages 533-539Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3136
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Funding
- Labex INFORM under the A*MIDEX program [ANR-11-LABX-0054, ANR-11-IDEX-0001-02]
- Agence Nationale de la Recherche (Programme Blance 'Archiplast')
- European Research Council [323027]
- Association pour la Recherche sur le Cancer [SL220120605305]
- National Health and Medical Research Council of Australia [1044041, 1037320]
- European Research Council (ERC) [323027] Funding Source: European Research Council (ERC)
- Agence Nationale de la Recherche (ANR) [ANR-11-LABX-0054] Funding Source: Agence Nationale de la Recherche (ANR)
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During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in mechanically coupling the contractile cortices of cells together, thereby distributing the stresses that drive cell rearrangements at both local and tissue levels. Here we discuss the concept that cellular contractility and E-cadherin-based adhesion are functionally integrated by biomechanical feedback pathways that operate on molecular, cellular and tissue scales.
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