Journal
NATURE BIOTECHNOLOGY
Volume 33, Issue 10, Pages 1076-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.3358
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Funding
- Ghent University, Belgium, (Bijzonder Onderzoeksfonds) [BOF2004GOA012, BOF2009G0A004]
- Research Foundation-Flanders (FWO) [3G012609, 35963]
- Agency for Innovation by Science AMP
- Technology (IWT)
- F.W.O
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Biofortification of staple crops could help to alleviate micronutrient deficiencies in humans. We show that folates in stored rice grains are unstable, which reduces the potential benefits of folate biofortification. We obtain folate concentrations that are up to 150 fold higher than those of wild-type rice by complexing folate to folate-binding proteins to improve folate stability, thereby enabling long-term storage of biofortified high-folate rice grains.
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