Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 59, Issue 12, Pages 7387-7395Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01458-15
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Funding
- CAPES
- Fleury Institute
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In Enterobacteriaceae, the bla(NDM) genes have been found in many different genetic contexts, and a wide diversity of plasmid scaffolds bearing those genes has been found. In August 2013, we identified NDM-1-producing Escherichia coli and Enterobacter hormaechei strains from a single rectal swab sample from a patient hospitalized in Rio de Janeiro, Brazil, who had no history of travel abroad. Complete DNA sequencing using the Illumina platform and annotation of the two plasmids harboring the bla(NDM-1) gene, one from each strain, showed that they belonged to incompatibility groups IncFII(K) and IncX3 and harbored a novel transposon named Tn3000. Similar genetic structures have been identified among other isolates in Brazil but also on plasmids from other continents. Our findings suggest that the bla(NDM-1) gene may be transmitted by Tn3000 in different parts of the world.
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