Journal
NATURE
Volume 526, Issue 7573, Pages 343-350Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature15817
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Funding
- NIH [P50 GM115279, RO1 CA36401, R24 GM115264, RO1 CA142665, P30 CA21765]
- American Lebanese Syrian Associated Charities
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After decades of discovery, inherited variations have been identified in approximately 20 genes that affect about 80 medications and are actionable in the clinic. And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a cornerstone for precision medicine.
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