Journal
NATURE
Volume 517, Issue 7534, Pages 293-301Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature14189
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Funding
- US National Institutes of Health [AI061570, AI095603, AI074878, AI095466, AI106697, AI102942, AI097333]
- Crohns and Colitis Foundation of America
- Burroughs Wellcome Fund
- European Research Council [341038]
- European Research Council (ERC) [341038] Funding Source: European Research Council (ERC)
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The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate lymphoid cells are the most recently identified constituents of the innate immune system and have been the focus of intense investigation over the past five years. We summarize the studies that formally identified innate lymphoid cells and highlight their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer.
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