4.8 Article

Pharmacogenomic agreement between two cancer cell line data sets

Journal

NATURE
Volume 528, Issue 7580, Pages 84-+

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nature15736

Keywords

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Funding

  1. Novartis Institutes for BioMedical Research
  2. Wellcome Trust [086357, 102696]
  3. National Institutes of Health [1U54HG006097-01]
  4. Novartis
  5. Dr. Miriam and Sheldon Adelson Medical Research Foundation
  6. Slim Foundation
  7. EMBL-EBI
  8. Wellcome Trust Sanger Institute Post-Doctoral (ESPOD) programme
  9. Cancer Research UK Clinician Scientist Fellowship [A16629]

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Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two publicly available large-scale pharmacogenomics resources: The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer databases.

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