Journal
JOURNAL OF APPLIED PHYSICS
Volume 105, Issue 10, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3116136
Keywords
biological tissues; bio-optics; frequency modulation; optical correlation; optical modulation; phantoms; photoacoustic effect; thermoacoustics
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Funding
- Ministry of Research and Innovation (MRI)
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Frequency-domain photothermoacoustic (FD-PTA) imaging of biological tissues is presented and compared with the conventional time-domain methodology. We demonstrate that tissue imaging can be performed with high axial resolution without the necessity to employ short-pulse and high peak-power laser systems to generate acoustic transients. The presented analysis shows that depth information in the FD-PTA method can be recovered by using linear frequency-modulated (chirped) optical excitation and frequency-domain signal processing algorithms. The signal-to-noise ratio can be increased significantly using correlation processing, which can compensate for the small amplitude of acoustic waves typical to the periodic excitation mode. Additionally, narrow-band signal demodulation enables depth-specific and confocal tissue imaging using the optically induced photothermoacoustic effect. Application of the FD-PTA is demonstrated in experiments with turbid phantoms and ex vivo tissue specimens.
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