Journal
NATURE
Volume 522, Issue 7557, Pages 487-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature14411
Keywords
-
Categories
Funding
- CNPq Ciencia sem Fronteiras Brazil [248676/2013-0]
- Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (CAVD) [OPP1033115, OPP1092074, OPP1040753, OPP1032144]
- Cooperative Centers on Human Immunology from NIH [U19A1111825-01]
- National Center for Advancing Translational Sciences (NCATS) [UL1 TR000043]
- Robertson Foundation
- NCI/NIH [HHSN261200800001E]
- German Center for Infection Research (DZIF) [3BNC117]
- Mark and Lisa Schwartz Foundation
- CAVD [43307]
- Bill and Melinda Gates Foundation [OPP1040753] Funding Source: Bill and Melinda Gates Foundation
Ask authors/readers for more resources
HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was largely ineffective in pre-clinical and clinical settings and was therefore abandoned(1-3). However, recently developed single-cell-based antibody cloning methods have uncovered a new generation of far more potent broadly neutralizing antibodies to HIV-1 (refs 4, 5). These antibodies can prevent infection and suppress viraemia in humanized mice and nonhuman primates, but their potential for human HIV-1 immunotherapy has not been evaluated(6-10). Here we report the results of a first-in-man dose escalation phase 1 clinical trial of 3BNC117, a potent human CD4 binding site antibody(11), in uninfected and HIV-1-infected individuals. 3BNC117 infusion was well tolerated and demonstrated favourable pharmacokinetics. A single 30mg kg(-1) infusion of 3BNC117 reduced the viral load in HIV-1-infected individuals by 0.8-2.5 log(10) and viraemia remained significantly reduced for 28 days. Emergence of resistant viral strains was variable, with some individuals remaining sensitive to 3BNC117 for a period of 28 days. We conclude that, as a single agent, 3BNC117 is safe and effective in reducing HIV-1 viraemia, and that immunotherapy should be explored as a new modality for HIV-1 prevention, therapy and cure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available