Journal
JOURNAL OF APPLIED GENETICS
Volume 49, Issue 3, Pages 251-255Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/BF03195621
Keywords
association analysis; beef cattle; SNP polymorphism; thyroglobulin gene
Funding
- Chinese National Programmes for High Technology Research and Development [2002A A242011]
- Eleventh Five-Year National Science and Technology Support Project [2006BAD01A10]
- National 863 Program of China [2008BADB2B03]
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Thyroid hormones play an important role in regulating the metabolism and can affect the homeostasis of fat deposition. The gene encoding thyroglobulin (TG), producing the precursor for thyroid hormones, has been proposed as a positional and functional candidate gene for a QTL with an effect on fat deposition. In the present study, we identified 6 novel SNPs at the 3' flanking region of the TG gene. The SNP marker association analysis indicated that the SNP markers G133C, G156A, C220T and A506C were significantly associated with marbling score (P < 0.05, N=271). Animals with the new homozygote genotype had higher marbling scores than those with the other genotypes. Besides, the linkage disequilibrium analysis indicated that these 4 SNPs were completely linked (r(2) = 1). Results of this study suggest that the TG-gene-specific SNP may be a useful marker for meat quality traits in future marker-assisted selection programmes in beef cattle.
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