Journal
NATURAL PRODUCT RESEARCH
Volume 29, Issue 18, Pages 1761-1765Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.999061
Keywords
marine fungus; Phakellia fusca Thiele; tetramic acid; polyphenol; anti-inflammatory activity; antituberculosis activity
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Funding
- National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]
- Open Foundation of the Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA [MBSMAT-2013-02]
- Open-end Funds of Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology [2013HS005]
- Open Foundation of the Laboratory for Polar Science, Polar Research Institute of China [KP201305]
- National High Technology Research and Development Program (863 Program) [2012AA092104]
- National Natural Science Foundation of China [31270402, 21172230, 20902094, 81202876, 41176148, 21002110]
- Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]
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Fifteen compounds, including two tetramic acid derivatives, penicillenol A(1) (1) and penicillenol A(2) (2), six polyphenols containing both phenolic bisabolane sesquiterpenoid and diphenyl ether units, expansols A-F (3-8), together with six phenolic bisabolane sesquiterpenoids (9-14) and diorcinol (15), were isolated from the fermentation broth of the marine-derived fungus ZSDS1-F11 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by using extensive NMR spectroscopic and mass spectrometric analyses. Compounds 3-5, 7 and 8 showed potent COX-1 inhibitory activity with IC50 values of 5.3, 16.2, 30.2, 41.0 and 56.8M, respectively. Meanwhile, compounds 3-8 showed potent COX-2 inhibitory activity with IC50 values of 3.1, 5.6, 3.0, 5.1, 3.2 and 3.7M, respectively. In addition, compound 1 exhibited antituberculosis activity with 96.1% inhibition at concentration of 10M.
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