Journal
NATURAL PRODUCT RESEARCH
Volume 29, Issue 18, Pages 1711-1718Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.999333
Keywords
Morus alba L; soroceal B; sanggenol Q; cytotoxic activity; anti-inflammatory activity
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Funding
- National Natural Science Foundation of China [U09326024]
- National Basic Research Program of China [973 Program] [2011CB915503]
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Six Diels-Alder adducts (1-6) and nine prenylated flavanones (7-15) were isolated from the root bark of Morus alba L. Among them, soroceal B (1) and sanggenol Q (7) were new compounds. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D and 2D NMR techniques. Compounds 1-3, 9, 10, 12, 13 and 15 exhibited cytotoxic activity against five human tumour lines and compound 2 inhibited significantly selective cytotoxic activities towards HL-60 and AGS cells with IC50 of 3.4 and 3.6M. Compounds 3, 5, 9 and 12 exhibited moderate inhibitory activity against nitric oxide production in LPS-activated RAW264.7.
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