Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 69, Issue 4, Pages 863-870Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkt491
Keywords
schistosomiasis; Schistosoma spp; chemotherapy
Funding
- Swiss National Science Foundation [PPOOA-114941, PPOOP3_135170]
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Praziquantel has been the mainstay of schistosomiasis control since 1984 and widely distributed since 2006 through preventive chemotherapy programmes to school-aged children or at-risk populations. In addition, preschool-aged children are now recognized as a vulnerable population and a group for targeted treatment, but they may be difficult to dose correctly with the available productua racemate, based on the biologically active enantiomer (R-praziquantel) and the inactive distomer (S-praziquantel), which contributes the bitter taste and doubles the size of the tablets. Hence, a paediatric formulation is required, possibly enantiomerically pure. Developing such a product and extending its use to younger children should be pharmacologically guided, but limited data exist on pharmacokinetics and pharmacokinetic/pharmacodynamic correlations for praziquantel. This article presents available data on the chemistry, pharmacokinetics and pharmacodynamics of praziquantel, as well as R-praziquantel, and points to gaps in our knowledge.
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