Journal
NATURAL PRODUCT RESEARCH
Volume 30, Issue 3, Pages 322-326Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1058793
Keywords
Illicium jiadifengpi; sesquiterpene lactones; anti-HBV activity
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Funding
- National Natural Science Foundation of China [NSFC] [81172961]
- Fundamental Research Fund for Henan University of Traditional Chinese Medicine [2014KYYWF-ZZCX3-03]
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Two new seco-prezizaane-type sesquiterpenes, 3,4-dehydroneomajucin (1) and 1,2,3,4-tetradehydroneomajucin (2), were isolated from the fruits of Illicium jiadifengpi. The structure of these compounds was determined using 1D and 2D NMR and ESI-MS. The isolates were evaluated for their anti-hepatitis B virus activities on the Hep G2.2.15 cell line. The inhibitory rates of compounds 1 and 2 on the HBeAg and HBsAg expression were 30.08 +/- 3.09% and 11.43 +/- 1.92% at a concentrations of 68.00M and 7.88 +/- 1.21% and 16.96 +/- 4.24% at a concentration of 68.50M, respectively.
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