Journal
NATURAL PRODUCT RESEARCH
Volume 30, Issue 22, Pages 2590-2593Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1114941
Keywords
Aconitum spicatum; antileishmanial activity; Leishmania major; diterpenoid alkaloids
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Funding
- World Academy of Sciences for Developing World (TWAS) [11-010-RG/CHE/AS_G UNESCO FR: 3240262700]
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The crude extracts of tubers of Aconitum spicatum (Bruhl) Stapf were investigated for in vitro antileishmanial activity against Leishmania major. The dichloromethane extract at pH 2.5 showed antileishmanial activity with IC50 value of 27.10 +/- 0.0g/mL. Chromatographic purification of the dichloromethane extract led to isolation of three C-19 norditerpenoid alkaloids indaconitine (1), chasmaconitine (2) and ludaconitine (3). Compounds 3 and 2 showed antileishmanial activity with IC50=36.10 +/- 3.4 and 56.30 +/- 2.1g/mL, respectively. Compound 1 was less effective (IC50>100g/mL). The cytotoxicity of compounds 1, 2 and 3 studied against MCF7, HeLa and PC3 cancer cell lines and 3T3 normal fibroblast cell line did not show cytotoxicity at 30M.
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