Journal
NATURAL PRODUCT RESEARCH
Volume 30, Issue 10, Pages 1150-1155Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1046378
Keywords
red algae; terpenoids; eudesmanes; cytotoxicity; antifungal activity
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Funding
- Deanship of Students Affairs, King Abdulaziz University, Jeddah
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A new eudesmane sesquiterpenoid, eudesma-4(15),7-diene-5,11-diol (1) along with the known trinor-sesquiterene, teuhetenone (2), and a seco-eudesmane sesquiterpene, chabrolidione B (3), have been isolated from the Red Sea red alga Laurencia obtusa. The chemical structures were elucidated on the basis of extensive spectroscopic analysis. The antifungal and cytotoxic activities of the isolated metabolites were tested against several fungi, yeast and human mammary carcinoma cell line (MCF-7). Compounds 1 and 3 showed a much better activity [minimum inhibitory concentration (MIC): 2.9M] than that of amphotericin B (MIC: 4.6M). Interestingly, compound 2, the least active antifungal compound, retained the high anticancer activity against MCF-7 (22M) in comparison with cisplatin (59M), which was determined by employing lactate dehydrogenase assay. Compounds 1-3 are recorded here for the first time from algal flora. The chemotaxonomic importance of the isolated metabolites was discussed.
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