Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 66, Issue 9, Pages 2107-2111Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkr248
Keywords
HIV/AIDS; older patients; polypharmacy; drug-drug interactions; cardiovascular drugs
Funding
- SHCS
- Swiss National Science Foundation [108787, PMPDP3-122791/1]
- Department of Medicine, University Hospital Basel
- Gilead
- Bristol-Myers Squibb
- Boehringer Ingelheim
- Tibotec
- ViiVHealthcare
- Merck
- Abbott
- Merck Sharp Dohme
- Roche
- TRB Chemedica
- Essex
- Janssen
- Abbott Laboratories
- Medical Research Council [G0901364] Funding Source: researchfish
- Swiss National Science Foundation (SNF) [PMPDP3-122791] Funding Source: Swiss National Science Foundation (SNF)
- MRC [G0901364] Funding Source: UKRI
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Objectives: To compare the use of co-medication, the potential drug-drug interactions (PDDIs) and the effect on antiretroviral therapy (ART) tolerability and efficacy in HIV-infected individuals according to age, >= 50 years or,50 years. Methods: All ART-treated participants were prospectively included once during a follow-up visit of the Swiss HIV Cohort Study. Information on any current medication was obtained by participant self-report and medical prescription history. The complete treatment was subsequently screened for PDDIs using a customized version of the Liverpool drug interaction database. Results: Drug prescriptions were analysed for 1497 HIV-infected individuals: 477 age >= 50 and 1020 age <50. Older patients were more likely to receive one or more co-medications compared with younger patients (82% versus 61%; P<0.001) and thus had more frequent PDDIs (51% versus 35%; P<0.001). Furthermore, older patients tended to use a higher number of co-medications and certain therapeutic drug classes more often, such as cardiovascular drugs (53% versus 19%; P<0.001), gastrointestinal medications (10% versus 6%; P=0.004) and hormonal agents (6% versus 3%; P=0.04). PDDIs with ART occurred mainly with cardiovascular drugs (27%), CNS agents (22%) and methadone (6%) in older patients and with CNS agents (27%), methadone (15%) and cardiovascular drugs (11%) in younger patients. The response to ART did not differ between the two groups. Conclusions: The risk for PDDIs with ART increased in older patients who take more drugs than their younger HIV-infected counterparts. However, medication use in older and younger patients did not differ in terms of effect on antiretroviral tolerability and response.
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