Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 66, Issue -, Pages i15-i24Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkq438
Keywords
galactomannan; beta-d-glucan; PCR-based diagnosis; microscopic examination; cultures
Funding
- Pfizer
- Pfizer International Operations
- Pfizer Inc.
- Astellas Pharma
- bioMerieux
- Gilead Sciences
- Schering Plough
- Soria Melguizo SA
- European Union
- ALBAN program
- Spanish Agency for International Cooperation
- Spanish Ministry of Culture and Education
- Spanish Health Research Fund
- Instituto de Salud Carlos III
- Ramon Areces Foundation
- Mutua Madrilena Foundation
- Austrian Science Fund (FWF) [P174840]
- MFF Tirol
- Merck Sharp
- Dohme
- Ministry of Health of the Czech Republic
- Schering-Plough/MSD
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A comprehensive review of diagnostic techniques for opportunistic systemic mycoses focused on invasive mould disease in immunocompromised patients is presented. We first analysed conventional diagnostic methods, such as microscopy examination, culture and radiology, underlining their limitations, which have led to the development of alternative methods, such as the detection of fungal components. Among these we highlight fungal antigen and DNA quantification, which make it possible to detect infections early and start appropriate treatment. We also briefly review the methods for carrying out susceptibility tests for antifungal drugs, including reference procedures, commercial techniques and their indications. Furthermore, we analyse the recommendations for therapeutic drug monitoring of antifungal agents in body fluids.
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