Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 64, Issue 6, Pages 1123-1125Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkp359
Keywords
CAP; guidelines; prescribing; antibiotic policy; antibiotic stewardship; collateral damage
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Antibiotic guidelines for community-acquired pneumonia (CAP) often recommend broad-spectrum agents for severe pneumonia. While these may be entirely appropriate in terms of their spectrum of activity and efficacy, there is a risk that such recommendations could result in over-prescribing of broad-spectrum agents with consequent 'collateral damage', meaning superinfection by resistant pathogens, or selection of antibiotic resistance. Narrow-spectrum agents are often as effective and result in less collateral damage. National and local antibiotic guidance should promote choices of agents for narrow-spectrum prescribing even for severe CAP where appropriate.
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