Journal
NATURAL PRODUCT REPORTS
Volume 32, Issue 3, Pages 411-435Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4np00089g
Keywords
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Funding
- U.S. National Institutes of Health (National Institute of General Medical Sciences) [2R01GM077379-06]
- University of California Santa Barbara
- CNRS
- Agence Nationale de la Recherche (France) [Aquaneurotox ANR-12-ASTR-0037-01]
- Eli Lilly
- Amgen
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From a small group of exotic compounds isolated only two decades ago, Cyclic Imine (CI) toxins have become a major class of marine toxins with global distribution. Their distinct chemical structure, biological mechanism of action, and intricate chemistry ensures that CI toxins will continue to be the subject of fascinating fundamental studies in the broad fields of chemistry, chemical biology, and toxicology. The worldwide occurrence of potent CI toxins in marine environments, their accumulation in shellfish, and chemical stability are important considerations in assessing risk factors for human health. This review article aims to provide an account of chemistry, biology, and toxicology of CI toxins from their discovery to the present day.
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