Journal
JOURNAL OF ANTIBIOTICS
Volume 67, Issue 6, Pages 445-450Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2014.14
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Funding
- Takeda Science Foundation
- JSPS KAKENHI [25870704]
- Grants-in-Aid for Scientific Research [25870704] Funding Source: KAKEN
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Citridone A (1), originally isolated as a potentiator of antifungal miconazole activity from a fungal culture broth, has a phenyl-R-furopyridone structure. Because of its unique ring structure, 11 derivatives were chemically synthesized and their biological activity was evaluated. Derivatives 17, 20 and 21 potentiated miconazole activity against Candida albicans. Furthermore, 1, 14, 20 and 21 were found to inhibit yellow pigment production in methicillin-resistant Staphylococcus aureus.
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