Journal
JOURNAL OF ANTIBIOTICS
Volume 67, Issue 6, Pages 451-457Publisher
SPRINGERNATURE
DOI: 10.1038/ja.2014.24
Keywords
Aegiceras corniculatum; anti-tuberculosis; antiviral; benzaldehyde; cytotoxicity; endophytic fungi; Pestalotiopsis sp AcBC2
Funding
- National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]
- National High Technology Research and Development Program (863 Program) [2012AA092104]
- National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]
- Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]
- Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012 D01 001, GD2012 D01 002]
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Five alkenyl phenol and benzaldehyde derivatives, pestalols A-E (1-5), as well as seven known compounds (6-12), were isolated from endophytic fungus Pestalotiopsis sp. AcBC2 derived from the Chinese mangrove plant Aegiceras corniculatum. Their structures were determined by spectroscopic analyses. Compounds 2 and 3 showed cytotoxicity against a panel of 10 tumor cell lines. Compounds 1-5, 8, 9, 11, and 12 showed inhibitory activities against Influenza A virus subtype (H3N2) and Swine Flu (H1N1) viruses. Compound 2 also showed inhibitory activity against tuberculosis.
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