Related references
Note: Only part of the references are listed.Aminoglycoside Antibiotics in the 21st Century
Bernd Becker et al.
ACS CHEMICAL BIOLOGY (2013)
Characterization of the Polymyxin B Resistome of Pseudomonas aeruginosa
Luca Fernandez et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors
Kiran S. Toti et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK)
Gabriel Martinez-Botella et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
The Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains
Riccardo Villa et al.
JOURNAL OF BACTERIOLOGY (2013)
Thiolates Chemically Induce Redox Activation of BTZ043 and Related Potent Nitroaromatic Anti-Tuberculosis Agents
Rohit Tiwari et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Tuning the Moenomycin Pharmacophore To Enable Discovery of Bacterial Cell Wall Synthesis Inhibitors
Christian M. Gampe et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
From natural product to marketed drug: the tiacumicin odyssey
William Erb et al.
NATURAL PRODUCT REPORTS (2013)
A genomic approach to the cryptic secondary metabolome of the anaerobic world
Anne-Catrin Letzel et al.
NATURAL PRODUCT REPORTS (2013)
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis
Lasse Jenner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
INFECTIOUS DISEASE Approval of Novel TB Drug Celebrated-With Restraint
Jon Cohen
SCIENCE (2013)
Comparison of Small Molecule Inhibitors of the Bacterial Cell Division Protein FtsZ and Identification of a Reliable Cross-Species Inhibitor
David E. Anderson et al.
ACS CHEMICAL BIOLOGY (2012)
Redesign of Glycopeptide Antibiotics: Back to the Future
Robert C. James et al.
ACS CHEMICAL BIOLOGY (2012)
In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound
Thomas A. Keating et al.
ACS CHEMICAL BIOLOGY (2012)
Myxobacterium-Produced Antibiotic TA (Myxovirescin) Inhibits Type II Signal Peptidase
Yao Xiao et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I
Alex G. Therien et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Mechanism of Action of the Arylomycin Antibiotics and Effects of Signal Peptidase I Inhibition
Peter A. Smith et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Regulated Assembly of the Transenvelope Protein Complex Required for Lipopolysaccharide Export
Elizaveta Freinkman et al.
BIOCHEMISTRY (2012)
Biosynthesis of new lipopentapeptides by an engineered strain of Streptomyces sp.
Xu Jin et al.
BIOTECHNOLOGY LETTERS (2012)
Fidaxomicin: A Novel Macrocyclic Antibiotic Approved for Treatment of Clostridium difficile Infection
Anilrudh A. Venugopal et al.
CLINICAL INFECTIOUS DISEASES (2012)
Tuberculosis: The drug development pipeline at a glance
Baptiste Villemagne et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action
Katherine A. Sacksteder et al.
FUTURE MICROBIOLOGY (2012)
New Drugs for the Treatment of Tuberculosis: Needs, Challenges, Promise, and Prospects for the Future
Christian Lienhardt et al.
JOURNAL OF INFECTIOUS DISEASES (2012)
Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials
Huaqing Cui et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead Generation
Jun Yong Choi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)
Gabriel Martinez-Botella et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Discovery of LFF571: An Investigational Agent for Clostridium difficile Infection
Matthew J. LaMarche et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-D-ribofuranose 2′-Oxidase DprE1
Claudia Trefzer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters
Dimitris Kallifidas et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
What counters antibiotic resistance in nature?
Remy Chait et al.
NATURE CHEMICAL BIOLOGY (2012)
Bugs, drugs and chemical genomics
Terry Roemer et al.
NATURE CHEMICAL BIOLOGY (2012)
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
Sarah M. Batt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor
David E. Ehmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens
Kevin J. Forsberg et al.
SCIENCE (2012)
Disulfide Rearrangement Triggered by Translocon Assembly Controls Lipopolysaccharide Export
Shu-Sin Chng et al.
SCIENCE (2012)
Cytoplasmic ATP Hydrolysis Powers Transport of Lipopolysaccharide Across the Periplasm in E-coli
Suguru Okuda et al.
SCIENCE (2012)
Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis
Joao Neres et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Synthetic Lethal Compound Combinations Reveal a Fundamental Connection between Wall Teichoic Acid and Peptidoglycan Biosyntheses in Staphylococcus aureus
Jennifer Campbell et al.
ACS CHEMICAL BIOLOGY (2011)
Phase 2, Randomized, Double-Blind, Dose-Ranging Study Evaluating the Safety, Tolerability, Population Pharmacokinetics, and Efficacy of Oral Torezolid Phosphate in Patients with Complicated Skin and Skin Structure Infections
P. Prokocimer et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Comparative Susceptibilities to Fidaxomicin (OPT-80) of Isolates Collected at Baseline, Recurrence, and Failure from Patients in Two Phase III Trials of Fidaxomicin against Clostridium difficile Infection
Ellie J. C. Goldstein et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses
Daniel W. Udwary et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2011)
A Head-to-Head Comparison of Eneamide and Epoxyamide Inhibitors of Glucosamine-6-Phosphate Synthase from the Dapdiamide Biosynthetic Pathway
Marie A. Hollenhorst et al.
BIOCHEMISTRY (2011)
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase
Sara Van Poecke et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics
Sang Ho Lee et al.
CHEMISTRY & BIOLOGY (2011)
Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus
John W. Phillips et al.
CHEMISTRY & BIOLOGY (2011)
Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design
Chul-Jin Lee et al.
CHEMISTRY & BIOLOGY (2011)
Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
Yi-Ming Chiang et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2011)
Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors
Ken Coleman
CURRENT OPINION IN MICROBIOLOGY (2011)
Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane
Tamimount Mohammadi et al.
EMBO JOURNAL (2011)
Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent
Weon Bin Im et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Fungal secondary metabolites - Strategies to activate silent gene clusters
Axel A. Brakhage et al.
FUNGAL GENETICS AND BIOLOGY (2011)
Prulifloxacin: a review focusing on its use beyond respiratory and urinary tract infections
Petros I. Rafailidis et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2011)
Antibiotics in the clinical pipeline in 2011
Mark S. Butler et al.
JOURNAL OF ANTIBIOTICS (2011)
ATP-Binding Site of Bacterial Enzymes as a Target for Antibacterial Drug Design
Veronika Skedelj et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Synthesis and Antibacterial Activity of Pentacyclines: A Novel Class of Tetracycline Analogs
Cuixiang Sun et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Initial Efforts toward the Optimization of Arylomycins for Antibiotic Activity
Tucker C. Roberts et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
A New DNA Gyrase Inhibitor Subclass of the Cyclothialidine Family Based on a Bicyclic Dilactam-Lactone Scaffold. Synthesis and Antibacterial Properties
Peter Angehrn et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Solid Phase Synthesis of Globomycin and SF-1902 A5
Francisco Sarabia et al.
JOURNAL OF ORGANIC CHEMISTRY (2011)
Imaging Mass Spectrometry and Genome Mining via Short Sequence Tagging Identified the Anti-Infective Agent Arylomycin in Streptomyces roseosporus
Wei-Ting Liu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Synthesis and Characterization of the Arylomycin Lipoglycopeptide Antibiotics and the Crystallographic Analysis of Their Complex with Signal Peptidase
Jian Liu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
A Redesigned Vancomycin Engineered for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria
Jian Xie et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ
Peter Sass et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Organic synthesis toward small-molecule probes and drugs
Stuart L. Schreiber
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Lipoprotein LptE is required for the assembly of LptD by the β-barrel assembly machine in the outer membrane of Escherichia coli
Gitanjali Chimalakonda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel
Elizaveta Freinkman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin
Shinichiro Fuse et al.
ACS CHEMICAL BIOLOGY (2010)
Cellular Pharmacokinetics of the Novel Biaryloxazolidinone Radezolid in Phagocytic Cells: Studies with Macrophages and Polymorphonuclear Neutrophils
Sandrine Lemaire et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Cellular Pharmacodynamics of the Novel Biaryloxazolidinone Radezolid: Studies with Infected Phagocytic and Nonphagocytic cells, Using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila
Sandrine Lemaire et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Comparative In Vitro Antimicrobial Activities of Torezolid (TR-700), the Active Moiety of a New Oxazolidinone, Torezolid Phosphate (TR-701), Determination of Tentative Disk Diffusion Interpretive Criteria, and Quality Control Ranges
Steven D. Brown et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Proteins Required for Lipopolysaccharide Assembly in Escherichia coli Form a Transenvelope Complex
Shu-Sin Chng et al.
BIOCHEMISTRY (2010)
Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in CIpP: A Model for the CIpX/CIpA-Bound State of CIpP
Dominic Him Shun Li et al.
CHEMISTRY & BIOLOGY (2010)
Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria
Anthony D'Onofrio et al.
CHEMISTRY & BIOLOGY (2010)
Uncultured microorganisms as a source of secondary metabolites
Kim Lewis et al.
JOURNAL OF ANTIBIOTICS (2010)
The Antibacterial Cell Division Inhibitor PC190723 Is an FtsZ Polymer-stabilizing Agent That Induces Filament Assembly and Condensation
Jose M. Andreu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Daptomycin, a Bacterial Lipopeptide Synthesized by a Nonribosomal Machinery
Lars Robbel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-D-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis
Claudia Trefzer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Development of an Activity Assay for Discovery of Inhibitors of Lipopolysaccharide Transport
Luisa S. Gronenberg et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Natural Products Version 2.0: Connecting Genes to Molecules
Christopher T. Walsh et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity
Bohdan Ostash et al.
NATURAL PRODUCT REPORTS (2010)
Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
Robert H. Cichewicz
NATURAL PRODUCT REPORTS (2010)
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
Byung-Gil Lee et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
FtsZ in Bacterial Cytokinesis: Cytoskeleton and Force Generator All in One
Harold P. Erickson et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2010)
Characterization of the two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at the outer membrane
Shu-Sin Chng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Nonconsecutive disulfide bond formation in an essential integral outer membrane protein
Natividad Ruiz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa
Nityakalyani Srinivas et al.
SCIENCE (2010)
Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II
Tanja Schneider et al.
SCIENCE (2010)
Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches
Igor Mochalkin et al.
ACS CHEMICAL BIOLOGY (2009)
Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue
Anna C. Haagsma et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model
K. N. Williams et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Safety, Tolerability, and Pharmacokinetics of PA-824 in Healthy Subjects
Ann M. Ginsberg et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Complete Characterization of the Seventeen Step Moenomycin Biosynthetic Pathway
Bohdan Ostash et al.
BIOCHEMISTRY (2009)
The discovery of antibacterial agents using diversity-oriented synthesis
Warren R. J. D. Galloway et al.
CHEMICAL COMMUNICATIONS (2009)
A Staphylococcus aureus Fitness Test Platform for Mechanism-Based Profiling of Antibacterial Compounds
Robert G. K. Donald et al.
CHEMISTRY & BIOLOGY (2009)
Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus
Joann Huber et al.
CHEMISTRY & BIOLOGY (2009)
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Helen W. Boucher et al.
CLINICAL INFECTIOUS DISEASES (2009)
The A-Z of bacterial translation inhibitors
Daniel N. Wilson
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2009)
Bacterial RNA Polymerase Inhibitors: An Organized Overview of their Structure, Derivatives, Biological Activity and Current Clinical Development Status
R. Mariani et al.
CURRENT MEDICINAL CHEMISTRY (2009)
Daptomycin: mechanisms of action and resistance, and biosynthetic engineering
Richard H. Baltz
CURRENT OPINION IN CHEMICAL BIOLOGY (2009)
Structures of RNA polymerase-antibiotic complexes
Mary X. Ho et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)
Crystal Structures of the Complexes between Vancomycin and Cell-Wall Precursor Analogs
Yasushi Nitanai et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Advances in the Understanding and Use of the Genomic Base of Microbial Secondary Metabolite Biosynthesis for the Discovery of New Natural Products
James B. McAlpine
JOURNAL OF NATURAL PRODUCTS (2009)
Characterization of the active site of S-aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin
Holly Heaslet et al.
JOURNAL OF STRUCTURAL BIOLOGY (2009)
New Syntheses of E7389 C14-C35 and Halichondrin C14-C38 Building Blocks: Double-Inversion Approach
Dae-Shik Kim et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Metagenomic approaches to natural products from free-living and symbiotic organisms
Sean F. Brady et al.
NATURAL PRODUCT REPORTS (2009)
Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens
Sophie Brinster et al.
NATURE (2009)
Telavancin
G. Ralph Corey et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
TIMELINE Transport of lipopolysaccharide across the cell envelope: the long road of discovery
Natividad Ruiz et al.
NATURE REVIEWS MICROBIOLOGY (2009)
The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis
Andreas H. Diacon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli
Ming-Ta Sung et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Vadim Makarov et al.
SCIENCE (2009)
Antibiotics for Emerging Pathogens
Michael A. Fischbach et al.
SCIENCE (2009)
The chemical versatility of natural-product assembly lines
Christopher T. Walsh
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design
Yanqiu Yuan et al.
ACS CHEMICAL BIOLOGY (2008)
Diversity-oriented synthesis - Towards the optimal screening collection: A synthesis strategy
Thomas E. Nielsen et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Rχ-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance
Eugene Skripkin et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus
Daniel R. Gentry et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis
R. Rustomjee et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibiotics
Jiacheng Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The RNA Polymerase Switch Region Is a Target for Inhibitors
Jayanta Mukhopadhyay et al.
CELL (2008)
Genome mining for novel natural product discovery
Gregory L. Challis
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Total biosynthesis:: in vitro reconstitution of polyketide and nonribosomal peptide pathways
Elizabeth S. Sattely et al.
NATURAL PRODUCT REPORTS (2008)
A quantitative analysis of kinase inhibitor selectivity
Mazen W. Karaman et al.
NATURE BIOTECHNOLOGY (2008)
Mining microbial genomes for new natural products and biosynthetic pathways
Gregory L. Challis
MICROBIOLOGY-SGM (2008)
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity
David J. Haydon et al.
SCIENCE (2008)
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
Adam W. Barb et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structure and function of an essential component of the outer membrane protein assembly machine
Seokhee Kim et al.
SCIENCE (2007)
Mutational analysis of the myxovirescin biosynthetic gene cluster reveals novel insights into the functional elaboration of polyketide backbones
Vesna Simunovic et al.
CHEMBIOCHEM (2007)
Incorporation of nonmethyl branches by lsoprenoid-like logic:: Multiple β-alkylation events in the biosynthesis of myxovirescin A1
Christopher T. Calderone et al.
CHEMISTRY & BIOLOGY (2007)
Diarylquinolines target subunit c of mycobacterial ATP synthase
Anil Koul et al.
NATURE CHEMICAL BIOLOGY (2007)
Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis
Yanqiu Yuan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
3-hydroxy-3-methylglutaryl-CoA-like synthases direct the formation of methyl and ethyl side groups in the biosynthesis of the antibiotic myxovirescin A
Vesna Simunovic et al.
CHEMBIOCHEM (2007)
Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis
Andrew L. Lovering et al.
SCIENCE (2007)
Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria
Dorte Frees et al.
MOLECULAR MICROBIOLOGY (2007)
Total synthesis of myxovirescin A(1)
Alois Fuerstner et al.
CHEMISTRY-A EUROPEAN JOURNAL (2007)
The antibiotic resistome: the nexus of chemical and genetic diversity
Gerard D. Wright
NATURE REVIEWS MICROBIOLOGY (2007)
Drugs for bad bugs: confronting the challenges of antibacterial discovery
David J. Payne et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
New antibiotics from bacterial natural products
Jon Clardy et al.
NATURE BIOTECHNOLOGY (2006)
The total synthesis of moenomycin A
James G. Taylor et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Genomic analyses lead to novel secondary metabolites
Arjun H. Banskota et al.
JOURNAL OF ANTIBIOTICS (2006)
Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms
Michael A. Fischbach et al.
CHEMICAL REVIEWS (2006)
Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases
Vesna Simunovic et al.
CHEMBIOCHEM (2006)
Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu
Andrea Parmeggiani et al.
BIOCHEMISTRY (2006)
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
J Wang et al.
NATURE (2006)
Lipid II as a target for antibiotics
E Breukink et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Discovery of FabH/FabF inhibitors from natural products
K Young et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Sampling the antibiotic resistome
VM D'Costa et al.
SCIENCE (2006)
Structural basis for transcription inhibition by tagetitoxin
DG Vassylyev et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
H Brötz-Oesterhelt et al.
NATURE MEDICINE (2005)
Inhibition of bacterial RNA polymerase by streptolydigin: Stabilization of a straight-bridge-helix active-center conformation
S Tuske et al.
CELL (2005)
Colistin: The revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections
ME Falagas et al.
CLINICAL INFECTIOUS DISEASES (2005)
Emergence of daptomycin resistance in Enterococcus faecium during daptomycin therapy
K Sabol et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
Properties and structure-activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I
JA Robinson et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
EA Campbell et al.
EMBO JOURNAL (2005)
Glycopeptide and lipoglycopeptide antibiotics
D Kahne et al.
CHEMICAL REVIEWS (2005)
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
K Andries et al.
SCIENCE (2005)
The impact of bacterial genomics on natural product research
HB Bode et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Polyketide and nonribosomal peptide antibiotics: Modularity and versatility
CT Walsh
SCIENCE (2004)
Structure-activity relationships of globomycin analogues as antibiotics
T Kiho et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics
STD Hsu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Abyssomicin C - A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway
B Bister et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
Myxovirescin analogues via macrocyclic ring-closing metathesis
S Content et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Vancomycin assembly: Nature's way
BK Hubbard et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Genetics and assembly line enzymology of siderophore biosynthesis in bacteria
JH Crosa et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2002)
Isolating uncultivable microorganisms in pure culture in a simulated natural environment
T Kaeberlein et al.
SCIENCE (2002)
Protein kinases - the major drug targets of the twenty-first century?
P Cohen
NATURE REVIEWS DRUG DISCOVERY (2002)
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines
CT Walsh et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2001)
Evolution - Humans as the world's greatest evolutionary force
SR Palumbi
SCIENCE (2001)
Linezolid resistance in a clinical isolate of Staphylococcus aureus
S Tsiodras et al.
LANCET (2001)
Structural mechanism for rifampicin inhibition of bacterial RNA polymerase
EA Campbell et al.
CELL (2001)
Quinupristin/dalfopristin: A therapeutic review
DR Allington et al.
CLINICAL THERAPEUTICS (2001)
Crystal structure and total synthesis of globomycin: Establishment of relative and absolute configurations
H Kogen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Development of daptomycin for Gram-positive infections
FP Tally et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2000)
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
CK Stover et al.
NATURE (2000)
Enzymes of vancomycin resistance:: the structure of D-alanine-D-lactate ligase of naturally resistant Leuconostoc mesenteroides
AP Kuzin et al.
STRUCTURE WITH FOLDING & DESIGN (2000)
Target-oriented and diversity-oriented organic synthesis in drug discovery
SL Schreiber
SCIENCE (2000)
Vancomycin resistance in enterococci: reprogramming of the D-Ala-D-Ala ligases in bacterial peptidoglycan biosynthesis
VL Healy et al.
CHEMISTRY & BIOLOGY (2000)
Share Paper
