Journal
JOURNAL OF ANTIBIOTICS
Volume 66, Issue 6, Pages 333-337Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2013.19
Keywords
polyketide; Streptomyces
Funding
- Program for Promotion of Basic and Applied Researches for innovations in Bio-oriented Industry
- KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [25350981] Funding Source: KAKEN
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Although all Streptomyces strains are now thought to have 20-30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we searched new metabolites other than cytotrienin derivatives. Following the cultivation with new media and the peak-guided fractionation, we have found new compounds with new polyketide scaffold, named linearolides A and B.
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