Journal
JOURNAL OF ANTIBIOTICS
Volume 67, Issue 2, Pages 171-174Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2013.104
Keywords
cytotoxicity; Eutypella sp.; pimarane diterpenes; secondary metabolites
Funding
- National Hi-tech R&D Program of China (863 Program) [SS2012AA09160703]
- National Natural Science Foundation of China (NSFC) [41306197]
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Two new diterpenes, libertellenone G(1) and libertellenone H(2) were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of Arctic, together with two known pimarane diterpenes (3-4). The structures of 1 and 2 were elucidated from spectroscopic data (nuclear magnetic resonance, mass spectrometry and infrared). These compounds were evaluated for cytotoxic activity against seven human tumor cell lines. Compound 2 showed a range of cytotoxicity between 3.31 and 44.1 mu M. Compound 1 exhibited antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.
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