Journal
JOURNAL OF ANTIBIOTICS
Volume 67, Issue 4, Pages 315-318Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2013.135
Keywords
anti-H1N1 virus; antioxidation; Aspergillus terreus; cytotoxicity; marine-derived fungus; rubrolides
Funding
- NSFC [21172204, 41376148, 31071586]
- 973 Program of China [2010CB833804]
- 863 Program of China [2012AA092104, 2013AA092901]
- Special Fund for Marine Scientific Research in the Public Interest of China [2010418022-3]
- Shandong Natural Science Foundation [ZR2009CQ030]
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Two new rubrolides, rubrolides R (1) and S (2), were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus OUCMDZ-1925. Their structures were elucidated on the basis of spectroscopic analysis and X-ray single crystal diffraction. Compound 1 showed comparable or superior antioxidation against 2,2 '-azino-di(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals to those of trolox and ascorbic acid with an IC50 value of 1.33mM. Compound 2 showed comparable or superior anti-influenza A (H1N1) virus activity to that of ribavirin with an IC50 value of 87.1 mu M. Both compounds 1 and 2 showed weak cytotoxicity against the K562 cell line with IC50 values of 12.8 and 10.9 mu M, respectively.
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