Journal
JOURNAL OF ANTIBIOTICS
Volume 66, Issue 11, Pages 655-661Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2013.65
Keywords
absolute configurations; antimicrobial activity; enantiomers; Marfey's method; phenethylamine derivatives
Funding
- Ministry of Science and Technology of China [2009CB522300, 2012ZX09301002-003]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014287]
- program for New Century Excellent Talents in University [NCET-10-0120]
- Fok Ying Tung Education Foundation from the Ministry of Education of China [121039]
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Five new phenethylamine (PEA) derivatives (1-5) were isolated from the strain of Arenibacter nanhaiticus sp. nov. NH36A(T) derived from the marine sediment of the South China Sea by bioassay-guided fractionation. Their structures were elucidated by spectroscopic methods including UV, IR, HR-MS and NMR. Interestingly, compounds 1-4 existed as enantiomers, which were resolved by chiral liquid chromatography. The resolved configuration of each enantiomer was assigned by the Marfey's method. Of these compounds, 5 showed weak antimicrobial activity against Staphylococcus aureus and Bacillus subtilis with MIC values of 0.50 and 0.25 mg ml(-1), respectively.
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