Journal
JOURNAL OF ANTIBIOTICS
Volume 65, Issue 8, Pages 385-395Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2012.27
Keywords
antibiotics; bioactive microbial metabolites; biodiversity; future prospects; non-antibiotic bioactivities; taxonomic diversity
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The declining trends in microbial metabolite and natural products research and the refocusing of this research area are discussed. Renewing natural products research requires inexhaustible natural resources, as well as new genetic techniques and microbial sources, including endophytic microbes. The numbers of known bioactive metabolites are summarized according to their microbiological origin, biological activities and chemical structures. Synthetic and natural product-based libraries are also compared. Importantly, the wide range of microbial metabolite bioactivities, future trends and the importance of prioritizing natural products over synthetic compounds are emphasized. The Journal of Antibiotics (2012) 65, 385-395; doi:10.1038/ja.2012.27; published online 18 April 2012
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