Journal
JOURNAL OF ANTIBIOTICS
Volume 65, Issue 6, Pages 317-322Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2012.19
Keywords
Bacillus mojavensis; fengycins; iturin; mojavensin
Funding
- National High Technology Research and Development Program of China (863 Program) [2007AA09Z417, 2011AA09070404]
- Chinese Academy of Sciences [KSCX2-EW-G-16]
- National Science & Technology Pillar Program [2011BAE06B04]
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Three lipopeptides were isolated by bioactivity-guided fractionation from the fermentation broth of Bacillus mojavensis B0621A. A new iturinic lipopeptide, named mojavensin A (1), was tentatively characterized by 1D, 2D NMR and MS spectroscopy, Marfey's method containing a novel peptide backbone of L-Asn(1), D-Tyr(2), D-Asn(3), L-Gln(4), L-Pro(5), D-Asn(6), L-Asn(7) and an anteiso-type of the saturated beta-fatty acid side chain. Compound 2 and 3 were tentatively identified as iso-C16 fengycin B and anteiso-C17 fengycin B, respectively. These lipopeptides displayed dose-dependent antifungal activity against a broad spectra of phytopathogens and were weakly antagonistic to Staphylococcus aureus. Moreover, they all revealed cytotoxic activities against the human leukemia (HL-60) cell line. Mojavensin A, iso-C16 fengycin B, and anteiso-C17 fengycin B inhibited the growth of HL-60 with IC50 of 100, 100 and 1.6 mu M, respectively. The Journal of Antibiotics (2012) 65, 317-322; doi:10.1038/ja.2012.19; published online 11 April 2012
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