Journal
JOURNAL OF ANTIBIOTICS
Volume 65, Issue 8, Pages 413-417Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2012.40
Keywords
azaphilones; Chaetomium sp; chaetomugilins; cytotoxicity; dechlorine derivative
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [23590028] Funding Source: KAKEN
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Three new metabolites, chaetomugilin S, dechloro-chaetomugilin A and dechloro-chaetomugilin D, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated based on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and some chemical transformations. Particularly, chaetomugilins T and U are the first compouds without a chlorine atom in azaphilones isolated from this fungal strain, to date. In addition, these compounds moderately inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines. The Journal of Antibiotics (2012) 65, 413-417; doi:10.1038/ja.2012.40; published online 23 May 2012
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