Journal
JOURNAL OF ANTIBIOTICS
Volume 65, Issue 3, Pages 123-128Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2011.121
Keywords
fraction library; microbial metabolite; spiroacetal polyketide; Streptomyces griseochromogenes; structure elucidation
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [22681034, 24658088, 21580104] Funding Source: KAKEN
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Two new 6,6-spiroacetal polyketides, spirotoamides A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces griseochromogenes JC82-1223 by screening of structurally unique compounds based on a search of spectral database. The fraction library was constructed using a systematic separation method to efficiently discover new metabolites from microbial sources such as actinomycetes and fungi. The structures of 1 and 2 were elucidated by 2D-NMR and mass spectrometric measurements. They belong to a class of polyketides, and contain a 6,6-spiroacetal core structure and a carboxamide group. The biosynthetic pathway of 1 and 2 is discussed in the text. The Journal of Antibiotics (2012) 65, 123-128; doi:10.1038/ja.2011.121; published online 21 December 2011
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