Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655

In the course of discovering new metabolites from co-culture of Penicillium pinophilum FKI-5653 and Trichoderma harzianum FKI-5655, a new compound, designated secopenicillide C, and four known compounds, penicillide, MC-141, pestalasin A and stromemycin were isolated. The production of these compounds, except pestalasin A, was enhanced in co-culture to be two to six times higher than in pure culture of Penicillium pinophilum FKI-5653, which was the producer of these compounds. The Journal of Antibiotics (2011) 64, 769-774; doi:10.1038/ja.2011.91; published online 19 October 2011