Journal
JOURNAL OF ANTIBIOTICS
Volume 64, Issue 10, Pages 661-665Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2011.65
Keywords
actinomycete; antifungal activity; antimycins A(19) and A(20); Streptomyces antibioticus; X-ray diffraction
Funding
- National Natural Science Foundation of China [30873199]
- Program for New Century Excellent Talents in University [NCET-08-0612]
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Two new antimycin antibiotics, that is antimycins A(19) (1) and A(20) (2), were isolated from a cultured broth of marine actinomycete Streptomyces antibioticus H74-18 together with antimycins A(1a) (3a) and A(1b) (3b), A(2a) (4), A(3a) (5a) and A(3b) (5b). Their structures were determined by spectroscopic methods in combination with X-ray diffraction. Antimycin A(19) possessed a chiral acyl chain and an alkyl branch. The absolute configuration of chiral acyl chain in 1 was determined by X-ray diffraction analysis. Antimycin A(20) (2) has the shortest and simplest acetoxy acyl chain in the antimycins family. All the antimycins (1-5) showed potential antifungal activities against Candida albicans with MIC of about 5-10 mu g ml(-1). The Journal of Antibiotics (2011) 64, 661-665; doi:10.1038/ja.2011.65; published online 17 August 2011
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