Journal
JOURNAL OF ANTIBIOTICS
Volume 65, Issue 1, Pages 15-19Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2011.105
Keywords
diacylglycerol acyltransferase; fungal metabolites; inhibitor; isochaetochromin; Penicillium; triacylglycerol biosynthesis; gamma-pyrone
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18390008]
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [18390008] Funding Source: KAKEN
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A new bis-naphtho-gamma-pyrone isomer named isochaetochromin A(1) was isolated along with known isochaetochromins B-1 and B-2 from the culture broth of Penicillium sp. FKI-4942 by solvent extraction, silica gel column chromatography and HPLC. Among them, isochaetochromin B-1 showed the most potent inhibitory activity of triacylglycerol synthesis with an IC50 value of 5.6 mu M, followed by isochaetochromins B-2 (IC50, 11 mu M) and A1 (33 mu M). The Journal of Antibiotics (2012) 65, 15-19; doi: 10.1038/ja.2011.105; published online 23 November 2011
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