Journal
JOURNAL OF ANTIBIOTICS
Volume 63, Issue 12, Pages 703-708Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2010.114
Keywords
adipocyte; alkaline phosphatase; differentiation; mesenchymal stem cell; osteoblast
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Osteoblasts are the cells responsible for bone formation during embryonic development and adult life. Small compounds that could induce osteoblast differentiation might be promising sources of therapies for bone diseases such as osteoporosis. During screening for inducers of osteoblast differentiation of mouse pluripotent mesenchymal C3H10T1/2 cells, we isolated a small compound from the fermentation broth of Penicillium verruculosum CR37010. This compound, named decalpenic acid, bears a decalin moiety with a tetraenoic acid side chain. Treatment of C3H10T1/2 cells with decalpenic acid alone induced the expression of early osteoblast markers, such as alkaline phosphatase activity and osteopontin mRNA, but did not induce the late osteoblast marker osteocalcin mRNA or adipocyte markers under our experimental conditions. The Journal of Antibiotics (2010) 63, 703-708; doi:10.1038/ja.2010.114; published online 13 October 2010
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