Journal
JOURNAL OF ANTIBIOTICS
Volume 63, Issue 4, Pages 165-170Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2010.11
Keywords
alkaloid; deep ocean; fungus; Penicillium sp.
Funding
- Chinese Ocean Mineral Resource R D Association [DY 105-2-04]
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Four new alkaloids, including two new meleagrin analogs, meleagrin D (1) and E (2), and two new diketopiperazines, roquefortine H (3) and I(4), were isolated from a deep ocean sediment-derived fungus Penicillium sp. Meleagrin D (1) and E (2) possess unprecedented acetate mevalonate-derived side chains on the imidazole moiety. These new meleagrins showed weak cytotoxicity against the A-549 cell line, whereas meleagrin B (5) and meleagrin (6), which were isolated previously from the same strain, induced HL-60 cell apoptosis or arrested the cell cycle through G(2)/M phase, respectively. The results indicate that the distinct substitutions on the imidazole ring significantly influence the cytotoxicity of the meleagrin alkaloids. The Journal of Antibiotics (2010) 63, 165-170; doi:10.1038/ja.2010.11; published online 26 February 2010
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