Journal
JOURNAL OF ANTIBIOTICS
Volume 63, Issue 4, Pages 183-186Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2010.14
Keywords
anti-mycobacterial peptide; calpinactam; fungal metabolite; mycobactin; tuberculosis
Funding
- Kakenhi [16073215]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [19710191]
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [19710191, 16073215] Funding Source: KAKEN
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Calpinactam, a new anti-mycobacterial agent, was isolated from the culture broth of a fungal strain Mortierella alpina FKI-4905 by solvent extraction, octadecyl silane column chromatography and preparative HPLC. Calpinactam was active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibited the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 mu g ml(-1), respectively. The Journal of Antibiotics (2010) 63, 183-186; doi:10.1038/ja.2010.14; published online 26 February 2010
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