Journal
JOURNAL OF ANTIBIOTICS
Volume 62, Issue 11, Pages 631-634Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2009.82
Keywords
free radical scavenger; fungal metabolite; Phellinus sp KACC93057P; phellinins A1 and A2; styrylpyrone
Funding
- Rural Development Administration (RDA), Republic of Korea [20080401-034-069]
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Novel styrylpyrones, phellinins A1 and A2. were isolated together with known styrylpyrone compounds, hispidin and 1,1-distyrylpyrylethan, from the cultured broth of Phellinus sp. KACC93057P. These compounds were purified by solvent partition, Sephadex LH-20 column chromatography, C-18-solid phase extraction and finally by reversed-phase (ODS) TLC. To identify the phellinin producer Phellinus sp. KACC93057P, the ribosomal DNA (rDNA) internal transcribed space regions containing 5.8 rDNA were sequenced and compared with those of the known Phellinus isolates. Phellinus sp. KACC93057P was 94.8% identical to P baumii and P. linteus, all of which did not produce phellinins A1 and A2. These compounds significantly scavenged free radicals such as 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) and superoxide. The Journal of Antibiotics (2009) 62, 631-634; doi. 10.1038/ja.2009.82; published online 28 August 2009
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