Journal
JOURNAL OF ANTIBIOTICS
Volume 62, Issue 2, Pages 63-67Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2008.10
Keywords
atopic dermatitis; ceramidase; ceramidastin; Penicillium; Pseudomonas
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Decrease of ceramide in the skin is one of the aggravating factors of atopic dermatitis. The skin is often infected by ceramidase-producing bacteria, such as Pseudomonas aeruginosa. The bacterial ceramidase then degrades ceramide in the skin. To develop anti-atopic dermatitis drugs, we searched for ceramidase inhibitors, which led to the discovery of ceramidastin, a novel inhibitor of bacterial ceramidase, from the culture broth of Penicillium sp. Mer-f17067. Ceramidastin inhibited the bacterial ceramidase with an IC50 value of 6.25 mu g ml(-1). Here we describe the isolation, physicochemical properties, structure determination and biological activity of ceramidastin.
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