Journal
JOURNAL OF ANTIBIOTICS
Volume 61, Issue 3, Pages 149-157Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2008.124
Keywords
essramycin; triazolopyrimidine; marine Streptomyces sp.
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In the course of our screening program for new bio-active compounds, a novel triazolopyrimidine antibiotic, essramycin (1), was obtained from the culture broth of the marine Streptomyces sp., isolate Merv8102. Structure 1 was established by intensive NMR studies and by mass spectra. The compound is antibacterially active with MIC of 2 to 8 mu g/ml against Gram-positive and Gram-negative bacteria, while it showed no antifungal activity. The fermentation and isolation, as well as the structure elucidation and biological activity of 1 are described.
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