Journal
JOURNAL OF ANTIBIOTICS
Volume 61, Issue 4, Pages 245-249Publisher
SPRINGERNATURE
DOI: 10.1038/ja.2008.36
Keywords
marine-derived fungus; Aspergillus flavus; 5-hydroxy-2-pyrone; cAMP; GPR12
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Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated I might be a possible ligand for GPR12.
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