Journal
JOURNAL OF ANTIBIOTICS
Volume 61, Issue 10, Pages 615-622Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2008.81
Keywords
fungus; marine fish; Chaetomium sp.; cytotoxicity; chaetomugilins; COMPARE program
Funding
- Scientific Research on Priority Area Cancer
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- High Technology Research
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Chaetomugilins A similar to F have been isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses, including ID and 2D NMR techniques, some chemical transformations and an X-ray analysis. These compounds exhibited significant growth inhibition against cultured P388 cells and HL-60 cells. In addition, chaetomugilins A, C and F showed selective cytotoxic activities against 39 human cancer cell lines.
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