Journal
JOURNAL OF ANTIBIOTICS
Volume 61, Issue 11, Pages 668-674Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2008.94
Keywords
Bacillus marinus; macrolactin T; macrolactin U; structural elucidation; antibiotic activity
Funding
- NSFC [30672607]
- National Hi-Tech Projects [2006AA09Z446, 2006DFA31100, 2006AA09Z405, 2007AA09Z435]
- China Uni-PhD Base Project [20060001149]
- International Cooperation Projects of BMBF-MOST
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A new 24-membered macrolide macrolactin T (1), and a new polyene delta-lactone macrolactin U (2), along with macrolactins A, B, D, O, and S, were isolated from the cultured broth of the bacterium Bacillus marinus, which was isolated from Suaeda salsa collected in the coastline of Bohai Sea of China. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data analyses. The inhibitory activity of macrolactins T. B and D against fungi Pyricularia oryzae and Alternaria solani, and bacteria Staphylococcus aureus is reported.
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