Journal
JOURNAL OF ANIMAL SCIENCE
Volume 90, Issue -, Pages 263-265Publisher
OXFORD UNIV PRESS INC
DOI: 10.2527/jas.53802
Keywords
colon; beta-glucans; Laminaria digitata; Laminaria hyperborea; Saccharomyces cerevisiae; T (h)17
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An unregulated T(h)17 inflammatory response has been highlighted as a major contributor to the underlying pathology of inflammatory bowel diseases (IBD) whereas regulatory T (T-REG) cells) have been highlighted as pivotal in suppressing autoimmune and inflammatory responses in the gut. Following dietary supplementation, beta-glucans have been shown to reduce the T(h)17 signature molecule IL-17a in the porcine colon. To expand this observation we examined the effects of supplementing feeds with beta-glucans derived from seaweeds Laminaria hyperborea and Laminaria digitata and the yeast Saccharomyces cerevisiae on gene expression of a range of cytokines, receptors, and signal transducing molecules relevant to the T(h)17 and T-REG pathways in the porcine colon. All sources of beta-glucans significantly decreased the expression of T(h)17-related cytokines (IL-17a, IL-17F, and IL-22), receptor IL23R, and IL-6. There was no alteration to the T-REG-related target, Foxp3, or to TGF-beta, although a significant reduction in IL-10 was observed in the L. digitata supplementation group.
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