Journal
NANOTECHNOLOGY
Volume 26, Issue 27, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/26/27/274005
Keywords
AuNPs@MoS2 nanocomposite; electrochemical biosensor; hydrogen peroxide; nitric oxide
Funding
- National Basic Research Program of China [2012CB933301]
- National Natural Science Foundation of China [21305070, 21475064, 21375139, 21305051]
- Natural Science Foundation of Jiangsu Province [BK20130861]
- Ministry of Education of China [IRT1148, 20123223110007, 20133223120013]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Ask authors/readers for more resources
A novel hydrogen peroxide (H2O2) and nitric oxide (NO) biosensor was fabricated by immobilizing hemoglobin (Hb) on a gold nanoparticle-decorated MoS2 nanosheet (AuNPs@MoS2) nanocomposite film modified glass carbon electrode. The AuNPs@MoS2 nanocomposite not only made the immobilized Hb keep its native biological activity but also facilitated the electron transfer between electrode and the electroactive center of Hb due to its excellent conductivity and biocompatibility. The direct electrochemistry and bioelectrocatalytic activity of Hb were investigated by cyclic voltammetry (CV). The modified electrode showed good electrocatalytic ability toward the reduction of H2O2 and NO. Under optimal conditions, the current response was linear with the concentration of H2O2 and NO in the range from 10 to 300 mu M and 10 to 1100 mu M with a detection limit of 4 and 5 mu M, respectively. This MoS2-based biosensor was sensitive, reproducible and stable, indicating that AuNPs@MoS2 nanocomposite maybe a promising platform to construct electrochemical sensors for chemical and biological molecules detection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available