Journal
JOURNAL OF ANESTHESIA
Volume 23, Issue 2, Pages 298-300Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s00540-008-0721-4
Keywords
Transversus abdominis plane block; Lidocaine; Serum concentration
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We measured the serum concentration of lidocaine after transversus abdominis plane (TAP) block with 40 ml of 1% lidocaine in 12 patients under general anesthesia, using a fluorescence polarization immunoassay. The peak mean serum concentration of lidocaine occurred 30 min after the block (3.6 +/- 0.7 mu g center dot ml(-1)). The highest concentration of lidocaine (5.5 mu g center dot ml(-1)) was recorded 15 min after the block. These results indicate that a TAP block can potentially cause systemic toxicity of a local anesthetic. The analgesic effect of the TAP block may partially depend on the rise in serum concentration of the local anesthetic.
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