Journal
NANOTECHNOLOGY
Volume 26, Issue 5, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/0957-4484/26/5/055102
Keywords
ZnSe/ZnS quantum dots; chlorin e6; fluorescence resonance energy transfer (FRET); photodynamic therapy; cancer
Funding
- RFBR [12-02-01263, 12-02-00938]
- Government of Russian Federation [074-U01]
- Ministry of Education and Science of the Russian Federation [14.B25.31.0002]
- Science Foundation Ireland [12/IA/1300]
- Science Foundation Ireland (SFI) [12/IA/1300] Funding Source: Science Foundation Ireland (SFI)
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Stable water-soluble complexes of Cd-free ZnSe/ZnS quantum dots (QDs) and chlorin e6 complexes have been prepared. These complexes have shown approximately 50% intracomplex fluorescence resonance energy transfer from QDs to chlorin e6. The photodynamic therapy (PDT) test of the complexes against the Erlich acsite carcinoma cell culture demonstrated a twofold enhancement of the cancer cell photodynamic destruction as compared to that of free chlorin e6 molecules. It was shown that the PDT effect was significantly increased due to two factors: the efficient QD-chlorin e6 photoexcitation energy transfer and the improvement of cellular uptake of the photosensitizer in the presence of ZnSe/ZnS QDs.
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