Journal
JOURNAL OF ANALYTICAL CHEMISTRY
Volume 69, Issue 9, Pages 909-916Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S1061934814090081
Keywords
screening; determination; nerve agent; OPCW; LC-MS/MS
Categories
Funding
- Agency for Defense Development
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Qualitative screening procedures have been developed for the rapid detection and identification of the metabolites of nerve agents in the urine samples and extracts using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The combination of negative electrospray ionization (ESI) using a C-18 column and water-methanol mobile phase modified with ammonium formate provides a rapid screening procedure for nerve agent degradation products with limit of detection of 1 ng/mL in the precursor-ion analysis. Also, determination of the alkyl methylphosphonic acids was carried out by the SRM scan mode with the limit of detection of 0.1 ng/mL. These procedures will be applicable to the trace analysis of metabolites of nerve agents in human urine matrices in the Organisation for the Prohibition of Chemical Weapons (OPCW) proficiency test.
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